Chemijos instituto mokslininkų profiliai

Interesų / tyrimų tematikos / reikšminiai žodžiai

Organic chemistry, heterocyclization, reaction mechanisms, spectroscopy, protein engineering, NA tagging, synthetic cofactors

Nuoroda į išorinius profilius (ORCID, ResearchGate)

Viktoras Masevicius (0000-0002-3974-597X) (orcid.org)

(12) Viktoras Masevicius (researchgate.net)

Pagrindinės (visos) publikacijos

Publikacijos

Clarivative analytics referred publications

1. Vaidotas Stankevičius, Povilas Gibas, Bernadeta Masiulionytė, Liepa Gasiulė, Viktoras Masevičius, Saulius Klimašauskas, Giedrius Vilkaitis. Selective chemical tracking of Dnmt1 catalytic activity in live cells. Cell 2022, 1053-1065.e8.
2. Janina Ličytė, Kotryna Kvederavičiūtė, Audronė Rukšėnaitė, Eglė Godliauskaitė, Povilas Gibas, Vita Tomkutė, Gražina Petraitytė, Viktoras Masevičius, Saulius Klimašauskas, Edita Kriūkienė. Distribution and regulatory roles of oxidized 5-methylcytosines in DNA and RNA of the basidiomycete fungi Laccaria bicolor and Coprinopsis cinerea. Open Biol. 2022, 12:210302.
3. Rakauskaitė, R., Urbanavičiūtė, G., Simanavičius, M., Lasickienė, R.,Vaitiekaitė, A., Petraitytė, G., Masevičius, V., Žvirblienė, A., Klimašauskas, S., Photocage-SelectiveCapture and Light-Controlled Release of Target Proteins, ISCIENCE 2020, 23, 101833.
4. Gražina Petraitytė, Vytenis Vaitkevičius, Besra Özer, Viktoras Masevičius. Synthesis of 5-substituted and 5,6-disubstituted furo[2,3-d]pyrimidines from 2-methylthio-4,6-pyrimidindione and bifunctional electrophiles. Tetrahedron Lett. 2019, 1019-1021.
5. Milda Mickutė, Milda Nainytė, Lina Vasiliauskaitė, Alexandra Plotnikova, Viktoras Masevičius, Saulius Klimašauskas, Giedrius Vilkaitis. Animal Hen1 2′-O-methyltransferases as tools for 3′-terminal functionalization and labelling of single-stranded RNAs. NAR 2018, 46, e104.
6. Aleksandr Osipenko, Alexandra Plotnikova, Milda Nainytė, Viktoras Masevičius, Saulius Klimašauskas, and Giedrius Vilkaitis. Oligonucleotide-Addressed Covalent 3’-Terminal Derivatization of Small RNA Strands for Enrichment and Visualization. Chem. Int. Ed. 2017, 56, 6507–6510.
7. Masevičius, V., Nainytė, M., Klimašauskas, S. Synthesis of S-Adenosyl-L-Methionine Analogs with Extended Transferable Groups for Methyltransferase-Directed Labeling of DNA and RNA. Protoc. Nucleic Acid Chem. 2016, 64:1.36.1-1.36.13. doi: 10.1002/0471142700.nc0136s64
8. Gražina Petraitytė, Viktoras Masevičius. Synthesis of 5-(arylaminomethyl)furo[2,3-d]pyrimidine derivatives and cytotoxicity evaluation against some human solid tumor cell lines. Chemija, 2015, 4, 260-265.
9. Rasa Rakauskaitė, Giedrė Urbanavičiūtė, Audronė Rukšėnaitė, Zita Liutkevičiūtė, Robertas Juškėnas, Viktoras Masevičius and Saulius Klimašauskas. Biosynthetic Selenoproteins with Genetically-encoded Photocaged Selenocysteines. Commun. 2015, 51, 8245-8248.
10. Alexandra Plotnikova, Aleksandr Osipenko, Viktoras Masevičius, Giedrius Vilkaitis and Saulius Klimašauskas. Selective Covalent Labeling of miRNA and siRNA Duplexes Using HEN1 Methyltransferase. Am. Chem. Soc. 2014, 136, 13550−13553.
11. Robertas Juškėnas, Viktoras Masevičius, Sigitas Tumkevicius. Reactivity of Pyrimidine Nitrogen Atom toward an Acetal Moiety: Formation of 3-Ethoxy-2,3-dihydroimidazo[1,2-c]pyrimidines by Intramolecular Cyclization of N-4-(2,2-Diethoxyethyl) pyrimidine-4-amines. Synthesis, 2013; 45, 2438-2446.
12. Lukinavičius, M. Tomkuvienė, V. Masevičius and S. Klimašauskas. Enhanced chemical stability of AdoMet analogues for improved methyltransferase-directed labeling of DNA. ACS Chem. Biol., 2013, 8, 1134-1139.
13. Viktoras Masevicius, Grazina Petraityte, and Sigitas Tumkevicius. Synthesis of 4-amino-5-(arylaminomethyl)-2-methylthiofuro[2,3-d]pyrimidines via Mitsunobu reaction of 4-amino-5-(hydroxymethyl)-2-methylthiofuro[2,3-d]pyrimidine with N-mesyl- and N-nosylarylamines. Synthesis, 2012; 44, 1329-1338.
14. Viktoras Masevicius, Robertas Juskenas, and Sigitas Tumkevicius. Synthesis of Novel Pyrazolo[3,4-d]pyrimidines peri-Fused with 1,4-Diazepine, 1,4-Thiazepine, and 1,2,4-Triazepine Rings. Journal of Heterocyclic Chemistry 2012; 49, 315-320.
15. Zita Liutkevičiūtė, Edita Kriukienė, Indrė Grigaitytė, Viktoras Masevičius, and Saulius Klimašauskas. Methyltransferase-Directed Derivatization of 5-Hydroxymethylcytosine in DNA. Chem. Int. Ed. 2011, VIP, 50, 2090-2093.
16. Dodonova, I. Uogintaite, V. Masevicius, S. Tumkevicius. Palladium-catalyzed reaction of methyl-5-amino-4-chloro-2-methylthiopyrrolo[2,3-d]-pyrimidine-6-carboxylate with
    arylboronic acids. Synthesis of 1,3,4,6-tetraazadibenzo[cd,f]
    azulene heterocyclic system. Chem. Heterocycl. Comp., 2010, 1122-1126.
17. Tumkevicius, J. Dodonova, K. Kazlauskas, V. Masevicius, L. Skardziute, S. Jursenas. Synthesis and photophysical properties of oligoarylenes with pyrrolo[2,3-d]pyrimidine core. Tetrahedron lett., 2010, 3863-3871.
18. Liutkevičiūtė, G. Lukinavičius, V. Masevičius, D. Daujotytė, and S. Klimašauskas. Cytosine-5 methyltransferases add aldehydes to DNA. Nature Chem. Biol., Vol. 5, 2009, 400-402.
19. Masevicius, G. Petraityte, S. Tumkevicius. Reaction of 2-alkylthio-6-aminopyrimidin-4(3H)-ones with ethyl bromopyruvate. Synthesis of furo[2,3-d]pyrimidine and furo[3,2-e]imidazo[1,2-c]pyrimidine carboxylates. Chem. Heterocycl. Comp., 2009, 357-360.
20. Tumkevicius, V. Masevicius. Synthesis of 4-Alkynylpyrrolo[2,3-d]pyrimidines by the Palladium-Catalysed Cross-Coupling Reactions. Synthesis, 2007, 3815-3820.
21. Masevicius, R. Juskenas, S. Tumkevicius. Synthesis of a novel heterocyclic system – pyrazolo[5,4,3-de]pyrimido[4,5-e]-[1,4]diazepine. Khim. Geterotsikl. Soedin., 2007, 1878-1880. [Chem. Heterocycl. Comp., 2007, 1593-1594.

Patents

1. Klimasauskas S., Rakauskaite R., Masevicius V. Production of selenoproteins (SELPROT). EP 3019194 B1, 2018/10/17.
2. Klimasauskas S., Liutkevičiūtė Z., Masevicius V. Sequence analysis of 5-hydroxymethylcytosine in DNA. LT6340 (B), 2016/12/27.

1. Klimasauskas S., Liutkevičiūtė Z., Masevicius V. DNA strand scission analysis of 5-hydroxymethylated cytosines. LT6339 (B), 2016/12/27.

Projektai

2017-present   Single-cell temporal tracking of epigenetic DNA marks-EpiTrack. European Research Council, advanced grant. PI: Prof. Habil. Dr. S. Klimašauskas.

2015-present   Synthesis and functionalization of pyrimidine based condensed heterocycles, study on heterocyclization reactions. Vilnius University Faculty of Chemistry an Geosciences budget project. Project leader.

2013–2015       Direct single nucleotide mapping of genomic CpG marks. National Institute of Health, grant 1R21HG007200. PI: Prof. Habil. Dr. S. Klimašauskas.

2011-2015        Molecular tools for epigenomics and RNomics. Projects of the European Social Fund under Global Grant Measure, grant VP1-3.1-ŠMM-07-K-01-105. PI: Prof. Habil. Dr. S. Klimašauskas.

2014-2014        Characterization of bitumen structure utilising component, elemental analysis and functional group approach. Research project funded by Vilnius Gediminas Technical University, Faculty of Environmental Engineering, Road Research Institute. Project leader.

2012-2014        High Tech Materials Developing Research and Application. Research project funded by European Social Fund Agency (VP1-3.1-ŠMM-08-K-01-014). Task leader.

Several other earlier projects, also summer tutoring projects for students

Vadovavimas doktorantams, podoktorantūros stažuotojams

Two PhD defended under my supervision:

Gražina Petraitytė “Synthesis of 5-substituted and 5,6-Disubstituted furo[2,3-d]pyrimidines from pyrimidin-4(3H)-one and bifunctional electrophiles. Synthesis of 5-(arylaminomethyl)furo[2,3-d]pyrimidines via Mitsunobu reaction”, Vilnius University 2014.

Robertas Juškėnas “Synthesis of tricyclic heterosystems based on pyrazolo[3,4-d]pyrimidine framework. Study of intramolecular reaction of pyrimidine nitrogen with O,O-acetals”, Vilnius University 2014.

Dėstomi dalykai

Vilnius University, Faculty of Chemistry - General and Bioorganic chemistry (2005-2009); Protecting of Functional Groups in Organic Chemistry (2008-present); Organic Synthesis Methods (2014-2015); Organic chemistry: Mechanisms (2016-present); Biochemistry (2015-present). Also seminars, and tutorials on organic chemistry and spectroscopy.

Vadovavimas studentų darbams

20 BSc and 9 MSc students; 4 PhD students

Dalyvavimas komisijose, komitetuose

I am the elected member of the Senate of Vilnius University, member of Study Committee of the Senate, also I am a member of Chemistry Study Programme Committee.

Apdovanojimai

Theodorus von Grothus stipendium in 2000, couple certificates of appreciation for my work from Vilnius university rector.

Mokslo/studijų populiarinimo veikla

I gladly accept students for internship in my lab by Erasmus or other programs - last 5 years I had visiting students from France, UK, Germany and Turkey. Occasionally I give comments to press.

Kita

Preparation of study methodological material:

1. Masevičius, V., Nainytė, M., Klimašauskas, S. Synthesis of S-Adenosyl-L-Methionine Analogs with Extended Transferable Groups for Methyltransferase-Directed Labeling of DNA and RNA. Protoc. Nucleic Acid Chem. 2016, 64:1.36.1-1.36.13. doi: 10.1002/0471142700.nc0136s64
2. Viktoras Masevičius. „Funkcinių grupių apsaugos metodai (paskaitų konspektas)“. KTU leidykla „Technologija“, leidimo nr. 1, apimtis: 220 p., el. knygos leidimo metai: 2012; e.ISBN: 978-609-433-149-7; DOI: 10.5755/e01.9786094331497.
3. Eugenijus Butkus, Viktoras Masevičius, Sigitas Stončius. „Organinių reakcijų mechanizmų užduotys“. KTU leidykla „Technologija“, leidimo nr. 1, apimtis: 140 p., el. knygos leidimo metai: 2012; e.ISBN: 978-609-433-127-5. DOI:10.5755/e01.9786094331275

My expertise is outsourced by such companies as “Thermo Fisher Scientific Baltics” [contract signed in Vilnius 2015-01-09], Road Research Institute of Vilnius Gediminas Technical University [contract number 19972, signed in Vilnius 2019], some smaller companies.