Dr. Habil. Sigitas Tumkevičius
Phone: +370 5 2193197
Professor
Scientific Interests, Keywords
Organic chemistry, Heterocyclic Chemistry, Organometallic Chemistry, Photo- and Electroactive Organic Materials, OLED, Fluorescent Viscosity, Sensors, Biologically Active Compounds
Most important publications
- Serevičius, R. Skaisgiris, J. Dodonova, L. Jagintavičius, D. Banevičius, K. Kazlauskas, S. Tumkevičius, S. Juršėnas. Achieving Submicrosecond TADF Lifetime and Highly Efficient Electroluminescence by Fine Tuning of Phenoxazine-Pyrimidine Structure. ACS Applied Materials and Interfaces, 2020, 12, 10727−10736. https://dx.doi.org/10.1021/acsami.9b21394
- Toliautas, J. Dodonova, A. Žvirblis, I. Čiplys, A. Polita, A. Devižis, S. Tumkevičius, J. Šulskus, A. Vyšniauskas. Enhancing the Viscosity-Sensitive Range of a BODIPY Molecular Rotor by Two Orders of Magnitude. Chemistry – A European Journal, 2019, 25(44), 10342-10349; doi: 10.1002/chem.201901315.
- Maleckaite, J. Dodonova, S. Toliautas, R. Zilenaite, D. Jurgutis, V. Karabanovas, S. Tumkevicius, A. Vysniauskas. Designing a Red-Emitting Viscosity Sensitive BODIPY Fluorophore for Intracellular Viscosity Imaging. Chemistry – A European Journal 2021, 27, 16768-16775. https://doi.org/10.1002/chem.202102743
- Serevicius, T. Buciunas, J. Bucevicius, J. Dodonova, S. Tumkevicius, K. Kazlauskas, S. Jursenas. Room temperature phosphorescence vs. thermally activated delayed fluorescence in carbazole–pyrimidine cored compounds. Journal of Materials Chemistry C, 2018, 6, 11128-11136; DOI: 10.1039/c8tc02554a
- Serevičius, R. Skaisgiris, J. Dodonova, L. Jagintavičius, J. Bucevičius, K. Kazlauskas, S. Juršėnas, S. Tumkevičius. Emission wavelength dependence on the rISC rate in TADF compounds with large conformational disorder. Chemical Communications, 2019, 55, 1975-1978; DOI: 10.1039/c8cc08906j
- Serevičius, R. Skaisgiris, J. Dodonova, K. Kazlauskas, S. Juršėnas, S. Tumkevičius. Minimization of solid-state conformational disorder in donor–acceptor TADF compounds. Physical Chemistry Chemical Physics, 2020, 22, 265-272; DOI: 10.1039/C9CP05907E
- Serevičius, J. Dodonova, R. Skaisgiris, D. Banevičius, K. Kazlauskas, S. Juršėnas, S. Tumkevičius. Optimization of the carbazole–pyrimidine linking pattern for achieving efficient TADF. Journal of Materials Chemistry C, 2020, 8, 11192—11200; https://dx.doi.org/10.1039/d0tc02194f
- Serevičius, R. Skaisgiris, I. Fiodorova, G. Kreiza, D. Banevičius, K. Kazlauskas, S. Tumkevičius S. Juršėnas. Single-exponential solid-state delayed fluorescence decay in TADF compounds with minimized conformational disorder. Journal of Materials Chemistry C, 2021, 9, 836-841. https://doi.org/10.1039/D0TC05503D
- Maleckaitė, J. Dodonova-Vaitkūnienė, R. Žilėnaitė, S. Tumkevičius, A. Vyšniauskas. Red-Fluorescent BODIPY Molecular Rotor for High Microviscosity Environments. Methods and Applications in Fluorescence, 2022, 10, art.no. 034008; https://doi.org/10.1088/2050-6120/ac7943
- Jurgutis, G. Jarockyte, V. Poderys, J. Dodonova-Vaitkuniene, S. Tumkevicius, A. Vysniauskas, R. Rotomskis, V. Karabanovas. Exploring BODIPY-Based Sensor for Imaging of Intracellular Microviscosity in Human Breast Cancer Cells. International Journal of Molecular Sciences, 2022, 23, art.no. 5687; https://doi.org/10.3390/ijms23105687
Project and/or Grant leadership
1. Project of Lithuanian State Science and Study Foundation: “Study of Palladium-Catalyzed Reactions in Fused Pyrimidine Heterocycles” (2004) (Principal investigator).
2. Project of Lithuanian State Science and Study Foundation: “Study of Intramolecular Cyclization Reactions in 4-Substituted 5-Nitropyrimidines” (2005) (Principal investigator);
3. Project of Lithuanian State Science and Study Foundation: “Search for Anticancer Agents by Methods of Structural Thermodynamics” (2005, Joint project with Institute of Biotechnology, Supervisor of Vilnius University Team);
4. Project of Lithuanian State Science and Study Foundation: “Biotechnological Methods in Search of compounds specifically inhibitting human carbonic anhydrases” (2007-2009, Joint project with Institute of Biotechnology, Supervisor of Vilnius University Team);
5. Project of Lithuanian State Science and Study Foundation: “New Enzymes and Technologies for the Epygenome Analysis” (2007-2009, Joint project with Institute of Biotechnology, Supervisor of Vilnius University Team);
6. Project of Research Council of Lithuania: “Non-linear pi-Conjugated Heterocyclic Oligoarylenes: Synthesis and Properties” (OLIGOHET) (2010-2011) (Principal investigator).
7. ESFA project "Improvement of Chemistry and chemical engineering specialist training, development of staff qualification and mobility stimulation“ (VPI-2.2-ŠMM-09-V-01-006) of Intagrated national program "Sustainable chemistry". Supervisor of Vilnius University Team.
8. ESFA project No. VP1-3.1-ŠMM-08-K-01-004 “Synthesis and spectral characterization in wide spectral range of novel materials relevant to semiconductor- and nano-technologies by means of steady and ultrafast spectrometry” (2012-2015, executive and scientific team leader).
9. Lithuania Research Council Project „Novel functional pyrrolopyrimidines: Synthesis and Photophysical Properties (No. 027/2013, 2013-2015, principal investigator)
10. Project of the bilateral cooperation in scientific research and experimental development in Lithuanian and French integrated action program “Gilibert” “Cyclodextrins – supramolecular organocatalysts for the synthesis of substituted pyrrolo and pyrazolopyrimidines by multicomponent reactions” (2013-2014, principal investigator).
11. Joint Lithuanian–Latvian–Chinese (Taiwan) Tripartite Cooperation Programme Project „Synthesis of novel (deaza)purine-triazole conjugates and applications of their fluorescent properties“ (No. TAP-LLT-01/2015) (2015-2017, principal investigator).
12. Lithuania Research Council Project “Diazine-based 3rd generation emitters for organic optoelectronics” (No. S-MIP-17-73, 2017-2020, principal investigator).
13. EU Structural Funds (Lithuanian Science Council) “Development of advanced optoelectronic materials via smart molecular engineering” (No. 09.3.3-LMTK-718-01-0026), (2018-2022, investigator).
14. Lithuania Research Council Project “Next generation fluorescent viscosity sensors” (No. S-MIP-19-6, 2019-2022, investigator).
Supervision of Doctoral Students and/or Postdoc Students
1. Irina Fiodorova. Pyrimidine-Based Thermally Activated Delayed Fluorescence Emitters: Design, Synthesis and Photophysical Properties.
2. Jonas Bucevičius. Pyrrolo[2,3-d]pyrimidine-Based -Conjugated Fluorophores with 1,2,3-Triazole and Ethynyl Linkers: Synthesis and Photophysical Properties (2015)
3. Andžejus Voitechovičius. Synthesis and Photophysical Properties of Non-linear Arylpyrimidines (2013)
4. Jelena Dodonova. “Synthesis and Photophysical Properties of Pyrrolo[2,3-d]pyrimidine-Core Based Oligoarylenes” (2012 m.).
5. Edita Čapkauskaitė. Synthesis of Carbonic Anhydrase Inhibitors and Analysis of their Structure-Activity Relationship (2012)
6. Jurgis Sūdžius. Synthesis and Properties of Pyrimidine Derivatives – Potent Carbonic Anhydrase Inhibitors. (2011)
7. Mindaugas Dailidė. „Synthesis and DHFR Inhibitory Activity of 6-Substituted 2-Amino-4-oxo (or Amino)thieno[2,3-d]pyrimidine Derivatives” (2007).
8. Viktoras Masevičius. Synthesis, Properties and Heterocyclization Reactions of 4-Substituted 5-Amino-7H-Pyrrolo[2,3-d]pyrimidines (2005)
9. Živilė Ruželė. Investigation on the Synthesis of Acyclic and Carbocyclic Nucleoside Analogues and their Precursors. (2004)
10. Andrius Kaminskas. Synthesis and Investigation of Thieno- and Pyrrolo[2,3-d]pyrimidine Derivatives (2003)
Teaching Courses
“Fundamentals of Organic Chemistry”, “Methods of Organic Synthesis”, “Organometallic Chemistry”.
Supervision of Students' Thesis
Research advisor of graduation theses for bachelor and master degrees.
Participation in the national/international governing bodies, commissions, committees, boards etc.
Member of Editorial Board of Journal “Chemija” (2007 to present)
Member of Doctoral Committee of the Faculty of Chemistry and Geosciences (currently)
Member of the Council of the Faculty of Chemistry and Geosciences (until 2020)
Head of the group for the preparation of the study program "Pharmaceutical Chemistry" (2017)
Member of Editorial Board of Journal “Chemistry of Heterocyclic Compounds” (2009-2014)
Member of Vilnius University Senate (2002-2006; 2010 – 2015)
Member of the Study Committee of Vilnius University (2010-2014);
Awards
J. Matulis's Name Prize of Lithuanian Academy of Sciences (2022)
Lithuanian Science Prize (2013);
Vilnius University Rector’s Award - The best lecturer of the Chemistry Faculty of Vilnius University (2012);
Vilnius University Rector’s Award for Academic Achievements (2005);
Vilnius University Rector’s Award for Scientific Achievements (2003).
Other activities related to the development of the country's economy, culture and society
Member or chairman of the organizing committee of Lithuanian students’ scientific conferences “Chemistry and Chemical Technology” (2022-2015, 2013, 2012, 2009, 2006-2004);
Member of the organizing committee of Lithuanian chemists’ conferences “Chemistry 2011”, “Chemistry 2009”, “Chemistry 2007”, “Chemistry 2011”, “Chemistry 2005”
Chairman of Organizing Committee of the International Conference of the Lithuanian Chemical Society “Chemistry and Chemical Technology” Dedicated to Professor Vitas Dauksas on his 80th Birth Anniversary. (2015).
Member of Lithuanian Chemical Society
Textbooks and methodological tools:
1. Eduardas Tarasevičius, Sigitas Tumkevičius, Jelena Dodonova, Jonas Bucevičius, Vilma Petrikaitė, Liudas Šlepikas. “Pharmaceutical Chemistry of Heterocycles in Schemes” (in Lithuanian). – Vilnius: LFS Publishing Center, 2018, 731 p. (ISBN 978-9955-9568-3-9).
2. S. Tumkevičius. “Organometallic Chemistry” (in Lithuanian). – Vilnius: TEV, 2012, 202 p. (e-ISBN 978-609-433-120-6).
3. V. Gefenas, S. Tumkevičius “Synthesis Principles and Methods of Carbocyclic and Macrocyclic Compounds “(in Lithuanian). – Vilnius: VUE Publishing House, 2009, 59 p. (ISBN 978-9955-20-393-3).
4. A. Brukštus, S. Tumkevičius. “Chemistry of Heterocyclic Compounds” (in Lithuanian). – Vilnius: VUE Publishing House, 2008, 257 p. (ISBN 978-9955-20-310-0).
5. S. Tumkevičius, A. Brukštus „Nomenclature of Heterocyclic Compounds” (in Lithuanian). – Vilnius: VU Publishing House, 1998, 45 p.
6. E. Butkus, G. E. Purvaneckas, S. Tumkevičius. “Laboratory work in organic chemistry” (in Lithuanian). – Vilnius: VU Publishing House, 1988, 142 p.
7. E. Butkus, V. Daukšas, P. Kadziauskas, G. Purvaneckas, S.Tumkevičius, P. Vainilavičius. “Organic chemistry exercises and problems ". - Vilnius: VU Publishing House, 1983, 104 p.